Immunogenicity in Mice Conjugates and Evaluation of Their A Meningococcal Capsular Polysaccharide Preparation and Characterization of Group
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MOLECULAR CHARACTERIZATION AND OPTIMIZATION OF VI-CAPSULAR POLYSACCHARIDE OF SALMONELLA TYPHI TY6S PRODUCTION IN BIOREACTOR
The role of Vi-capsular polysaccharide (Vi-CPS) in human immunity against infection caused by Salmonella typhi is well known. The downstream process of purification generally causes depolymerization of Vi-CPS to a nonimmunogenic low molecular weight form. In the present study, a standard strain of Sal. typhi Ty6s was grown under submerge cultural conditions in a pilot-plant scale of 90 Liter fe...
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A method is presented for covalently bonding Haemophilus influenzae type b capsular polysaccharide (HIB Ps) to several proteins. The method is efficient and relies upon the use of adipic dihydrazide as a spacer between the capsular polysaccharide and the carrier protein. In contrast to the poor immunogenicity of the purified HIB Ps in mice and rabbits, the HIB Ps-protein conjugates induced seru...
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Neisseria meningitidis (meningococcus) is a Gram-negative human pathogen that causes meningococcal diseases, such as meningococcal meningitis and meningococcal septicemia. Based on the surface capsular oligosaccharides of the organism, 13 serogroups of N. meningitidis have been identified, among which A, B, C, Y, and W135 are the major pathogenic strains. Serogroup A is the pathogen most often ...
متن کاملPolysaccharide of meningococcal group C conjugated to different quantities of outer membrane vesicle from Neisseria meningitidis serogroup B
The immunogenicity to several meningococcal polysaccharide-protein conjugates was evaluated in mice. The purified polysaccharide from N. meningitidis serogroup C (PsC) was linked to different quantities of outer membrane vesicle from N. meningitidis serogroup B (OMV) (3, 6 and 9 mg) as carrier protein, via carbodiimide-mediated reaction. The conjugates were inoculated in Balb/c mice in three do...
متن کاملCurrent status of meningococcal group B vaccine candidates: capsular or noncapsular?
Meningococcal meningitis is a severe, life-threatening infection for which no adequate vaccine exists. Current vaccines, based on the group-specific capsular polysaccharides, provide short-term protection in adults against serogroups A and C but are ineffective in infants and do not induce protection against group B strains, the predominant cause of infection in western countries, because the p...
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تاریخ انتشار 2003